There are 11 papers on P53 mRNA in aging research: 1 trial and 1 observational study in people, 7 in animals, 2 in cells.
11 papers study it15 more mention it2 findings
2 new papers in 30 daysSee all 26 papers on P53 mRNA
- Human trial1
- Humans1
- Animals6
- Model organisms1
- Cells2
Interventions
2Nicotinamide
upin flies1
1 study
Nicotinamide
upin flies1
Nicotinamide increases P53 mRNA in flies (RasV12scrib-/- Drosophila model).
“significantly increased p53 mRNA levels”
Model organismsRasV12scrib-/- Drosophila model
Translational cancer research
Exercise training
downin humans1
1 study
Exercise training
downin humans1
Exercise training is linked with lower P53 mRNA in humans (aged lifelong exercise-trained vs aged untrained men).
“while lifelong exercise training increased BNIP3 protein and decreased p53 mRNA”
Humansaged lifelong exercise-trained vs aged untrained menlifelongskeletal musclelifelongmales
Experimental gerontology
Latest
5 papers in 12 monthsTissue & Cell
Fisetin promotes liver regeneration by inducing β-catenin-mediated inhibition of p53 and suppression of TGF-β
Experiments in 24 ratsFisetin
Translational Cancer Research
Vitamin B3 suppresses RasV12 -driven tumor growth in Drosophila via redox regulation, mitochondrial function, and autophagy activation
Experiments in fliesInterventions
American Journal of Physiology Renal Physiology
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy
Experiments in miceSGLT2 inhibitors
Biochemical and Biophysical Research Communications
Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury
Experiments in miceCellular senescence
Biogerontology
IL-6 deficiency attenuates p53 protein accumulation in aged male mouse hippocampus
Experiments in miceIL-6 signaling
The Journal of Physiology
Post-exercise carbohydrate and energy availability induce independent effects on skeletal muscle cell signalling and bone turnover: implications for training adaptation
Non-randomized trial in 9 peopleHigh-intensity interval training
Experimental Gerontology
Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training
Study in peopleExercise training
The Journals of Gerontology, Series A
Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium
Experiments in miceTP53