Myelination

Biomarker

1 paper

  • Humans1

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bioRxiv

Brain scan changes linked to vessel disease in squirrel monkeys

An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.

Preprint: experiments in animalsBiomarkers
medRxiv

Spinal cord charts map age patterns and disease differences

Different upper spinal cord measurements peaked at ages 29.7–44.1 years in reference charts based on scans of 10,159 healthy people aged 8–85.Different upper spinal cord measurements peaked at ages 29.7–44.1 years in reference charts based on scans of 10,159 healthy people aged 8–85.

Preprint: cross-sectional study of 10,159 peopleBiomarkers
bioRxiv

Cell counts may miss dementia-linked changes in human brains

An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.An observational analysis of human brain tissue compared gene activity and cell proportions across normal cognition, disease-related aging and dementia.

Preprint: study in peopleMechanisms
European Journal of Pharmacology

Tetanus vaccine ingredient improved learning and memory in aging mice

An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve fibres.An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve fibres.

Experiments in miceInterventions
Cell Reports

Myelin lipid buildup links to lysosomal defects in mice

Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.Profiling lysosomal fractions from mouse cortex from 3 to 24 months revealed an accumulation of myelin-derived glycosphingolipids that was most pronounced in microglia.

Experiments in miceLysosome