Markers of senescence

Biomarker

5 papers1 finding

  • Animals5

Upstream

1

CAST

downin mice1

1 study
  1. CAST decreases markers of senescence in mice.

    “At two years, CalpTG mice had preserved kidney tissue, less vascular remodelling and less markers of senescence than wild-type mice.”

    Animalsagingkidney

    Specific calpain inhibition protects kidney against inflammaging

    Scientific reports14 Aug 2017

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bioRxiv

Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways

Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.

Preprint: experiments in human cellsMuscle