CAST

3 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

3 independent labs in 2 countries
1 finding against

Funders: Amgen and 6 more
3 of 8 findings with company ties

Animals3

Effects

Lifespan

upin mice2no changein mice1

3 studies

CAST extends lifespan in mice (from 20.55 mo in WT to 24 mo in CalpOX (P = 0.0006)).
“CalpOX had a significant impact on longevity, increasing median survival from 20.55 mo in WT mice to 24 mo in CalpOX mice (P = 0.0006).”
Animalsskeletal muscle
Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span
Journal of applied physiology (Bethesda, Md. : 1985)1 Jul 2021
CAST has no effect on lifespan in mice.
“Nevertheless, CalpTG mice lifespan was not extended, due to the development of lethal spleen tumors.”
Animalsaging
Specific calpain inhibition protects kidney against inflammaging
Scientific reports14 Aug 2017
CAST extends lifespan in mice (by 3 months).
“extends survival of JNPL3 mice by 3 months to within the range of normal lifespan”
AnimalsJNPL3 mice
Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice
The Journal of neuroscience : the official journal of the Society for Neuroscience9 Jul 2014

Macrophage infiltration

downin mice1

1 study

CAST decreases macrophage infiltration in mice.
“CalpTG mice had reduced macrophage infiltration with aging”
Animalsagingkidney
Specific calpain inhibition protects kidney against inflammaging
Scientific reports14 Aug 2017