MAPKs

Biomarker

1 paper

  • Cells1

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Experimental Gerontology

Ketogenic diet improved heart function in aged mice

An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.

Experiments in miceKetogenic diet
Aging Cell

Blocking an enzyme improved muscle strength in mice

In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.

Experiments in miceMuscle
Neurochemical Research

Sorafenib reduced cognitive deficits in desflurane-exposed mice

In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive performance.In 18-month-old mice of both sexes exposed to 2% desflurane for two hours, sorafenib pretreatment restored CLOCK protein and improved cognitive performance.

Experiments in miceMechanisms
bioRxiv

DNA polymerase kappa supports genome repair in cultured neurons

In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers.In mouse and human neurons, depleting POLK reduced repair-associated DNA synthesis and induced senescence-like stress, while augmenting POLK lowered DNA damage markers.

Preprint: experiments in human cellsMechanisms