4 papers1 finding
Silymarin, quercetin and naringenin
downin rats1
Silymarin, quercetin and naringenin decreases NF-κB in rats.
“In addition, polyphenolic treatments increased SIRT1 levels and decreased NF-κB levels in hippocampus.”
AnimalsAged Sprague-Dawley ratshippocampus20 mg/kg/day4 weeksmales
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology14 Aug 2017
National Institute of Allergy and Infectious DiseasesUS$2.6mNational Heart, Lung, and Blood InstituteUS$1.7m
NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
National Institute of Allergy and Infectious DiseasesSanford Burnham Prebys Medical Discovery InstituteUS$741.2k1998–2028
Targeting Senescence Specific Mechanisms of NF-κB Activation to Reverse Chronic Pulmonary Fibrosis
National Heart, Lung, and Blood InstituteMayo Clinic RochesterUS$567.5k2024–2029
In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.