2 papers1 finding
Mortality
upin humans1
Liver age raises the risk of mortality in humans (HRperSD 1.43, 95% CI 1.30-1.58).
“accelerated liver (HRperSD [95%CI] = 1.43 [1.30-1.58]), immune (1.42 [1.29-1.57]), and heart (1.38 [1.25-1.53]) ageing were most strongly associated with higher mortality risk.”
Humans≤17-year follow-upn = 861
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality
medRxiv : the preprint server for health sciences10 Mar 2026Preprint
An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.
An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.An animal study mapped gene activity in mouse livers of multiple ages, linking senescence patterns to changes in gene patterns defining specialised liver zones.
In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.