CST3

CST3 raises the risk of mortality in humans (HRperSD 1.48, 95% CI 1.29-1.69).

“CST3 (1.48 [1.29-1.69]), and COL18A1 (1.47 [1.30-1.68]).”

Humansplasma≤17-year follow-upn = 861

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality

medRxiv : the preprint server for health sciences·10 Mar 2026Preprint

CST3 is associated with physical function in humans.

“Growth/differentiation factor 15, Insulin-like growth factor-binding protein 2, and Cystatin-C showed significant associations with inflammatory markers and measures of physical function (grip strength or gait speed).”

Humansplasman = 1,201

DIFFERENTIAL RESPONSES TO AGING AMONG THE TRANSCRIPTOME AND PROTEOME OF MESENCHYMAL PROGENITOR POPULATIONS

GSA 2025 abstract·31 Dec 2025