2 papers2 findings
Caloric restriction
downin humans1
Caloric restriction decreases immune age in humans (-0.62, P = 2.92 × 10−3).
“immune system (-0.65, P = 1.83 × 10−3; -0.62, P = 2.92 × 10−3)”
Human trial24 months
Effect of caloric restriction on organ-specific biological aging in a randomized clinical trial
Clinical nutrition (Edinburgh, Scotland)14 Mar 2026
Mortality
upin humans1
Immune age raises the risk of mortality in humans (HRperSD 1.42, 95% CI 1.29-1.57).
“immune (1.42 [1.29-1.57]), and heart (1.38 [1.25-1.53]) ageing were most strongly associated with higher mortality risk.”
Humans≤17-year follow-upn = 861
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality
medRxiv : the preprint server for health sciences10 Mar 2026Preprint
Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.
An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.
A study of 853 adults aged 20 to 94 years found antibody architecture broadly preserved, with age-associated signals concentrated in focal targets.A study of 853 adults aged 20 to 94 years found antibody architecture broadly preserved, with age-associated signals concentrated in focal targets.
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.