A cross-sectional study of 181 people linked retinal changes to brain shrinkage, blood markers of Alzheimer's disease and cognitive impairment.A cross-sectional study of 181 people linked retinal changes to brain shrinkage, blood markers of Alzheimer's disease and cognitive impairment.
Cross-sectional study of 181 Alzheimer's patients and cognitively unimpaired controlsAlzheimer's disease
Limit: Brain changes could precede retinal changes rather than follow them
An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.
Preprint: experiments in young and older squirrel monkeysBiomarkers
Limit: Whether the scan measure helps human diagnosis or treatment risk assessment remains untested
An observational study of 2,402 people, with a median age of 66.1 years, linked hearing loss to weaker connections between brain regions.An observational study of 2,402 people, with a median age of 66.1 years, linked hearing loss to weaker connections between brain regions.
A cross-sectional study of 487 people with high blood pressure and 165 controls found region-specific differences in grey matter volume across disease-duration groups.A cross-sectional study of 487 people with high blood pressure and 165 controls found region-specific differences in grey matter volume across disease-duration groups.
Brain scans from 4,098 women revealed greater gray matter volume and cortical thickness in specific regions among post-menopausal compared with pre-menopausal women.Brain scans from 4,098 women revealed greater gray matter volume and cortical thickness in specific regions among post-menopausal compared with pre-menopausal women.
In an observational study of 2,796 adults, a multimodal brain-age model predicted chronological age with an average error of 3.45 years.In an observational study of 2,796 adults, a multimodal brain-age model predicted chronological age with an average error of 3.45 years.
In an observational study of 1,802 adults, diabetes was linked to altered gene co-localization with gray matter, while metformin use was linked to greater stability.In an observational study of 1,802 adults, diabetes was linked to altered gene co-localization with gray matter, while metformin use was linked to greater stability.
In an analysis of 1,012 participants, higher blood pressure was linked to larger deep brain volumes compared with blood pressure below 120/80 millimetres of mercury.In an analysis of 1,012 participants, higher blood pressure was linked to larger deep brain volumes compared with blood pressure below 120/80 millimetres of mercury.
Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.
Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.Separating white and gray matter brain age highlights early cardiometabolic risks and divergent links to amyloid and tau pathology.