Amyloid angiopathy

Brain scan changes linked to vessel disease in squirrel monkeys

An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.An animal experiment compared scans with brain tissue in young and older squirrel monkeys, linking an imaging measure to amyloid vessel disease and tissue injury.

Limit: Whether the scan measure helps human diagnosis or treatment risk assessment remains untested

Sleep's link to brain damage varies with other vessel injuries

In an observational study of 735 people, other brain vessel injuries strengthened links between shorter sleep and brain lesions in some diagnostic groups.In an observational study of 735 people, other brain vessel injuries strengthened links between shorter sleep and brain lesions in some diagnostic groups.

Severely enlarged brain vessel spaces predicted bleeding lesions

Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.Over a median 5.1 years, bleeding-related lesions appeared in 33.7% of participants with severe enlargement versus 13.6% without severe enlargement.

App knock-in mice display age-dependent Alzheimer's pathology

In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.In a study of App SAA knock-in mice from 4 to 19 months, animals developed progressive amyloid pathology, neuroinflammation, biomarker shifts, and synaptic loss.