Neurofibrillary tangles
Biomarker1 paper1 finding
- Humans1
Upstream
1Extreme limits of age
upin humans1
1 study
Extreme limits of age
upin humans1
Extreme limits of age increases neurofibrillary tangles in humans.
Humansbrain
Neuropathology of centenarians and supercentenarians: An autopsy study · Neurobiology of aging · 16 Sep 2026
Funding
National Institute on AgingUS$2.4m1 grant since 2026
Latest
26medRxivHumansPreprint
Blood eMTBR-tau linked to Alzheimer’s tangles at autopsy
Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.Classification accuracy remained high (AUC=0.91–0.95) up to a decade before death, with higher sensitivity and specificity than plasma p-tau217.
bioRxivModel organismsPreprint
Progressive behavioral and cognitive decline in Drosophila harboring AD- associated APOE4 variants
Neurobiology of AgingHumans
Neuropathology of centenarians and supercentenarians: An autopsy study
Frontiers in Molecular NeuroscienceAnimals
Investigating the role of EFhd2 protein in modulating tau pathology in a tauopathy mouse model
AAIC 2025 AbstractHumans