Relative risk measures were 0.72 for Alzheimer’s and 1.95 for vascular dementia, comparing systolic pressures of at least 160 versus 120 to below 140 millimetres of…Relative risk measures were 0.72 for Alzheimer’s and 1.95 for vascular dementia, comparing systolic pressures of at least 160 versus 120 to below 140 millimetres of mercury.
Cohort study of 2,649 older Japanese-American men without dementia, against men with 120 to <140 mmHgVascular dementia
Limit: Only 88 vascular dementia cases leave the estimated increase in risk imprecise
In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.In an animal experiment, 18-month-old mice given the compound for 28 days also showed better spatial memory, without changes in movement.
Preprint: experiments in aged mice, 28 days, against untreated aged miceInterventions
Limit: Treatment lasted only 28 days, leaving the durability of stem-cell expansion unclear
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.