Fibroblasts
Biomarker1 paper1 finding
- Humans1
Upstream
1Clonal hematopoiesis
upin humans1
1 study
Clonal hematopoiesis
upin humans1
Clonal hematopoiesis increases fibroblasts in humans.
Humansbone marrow
Clonal hematopoiesis remodels human bone marrow into an inflammatory prefibrotic environment · Nature immunology · 30 Sep 2026
Latest
23Genetic susceptibility, risk prediction, and druggable targets for oropharyngeal cancer: a UK Biobank study
SASP factors drive growth of altered cancer cells in culture
Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to…Using a microarray platform, researchers identified shared growth drivers in breast and lung cancer cells that required cellular alterations to promote proliferation.
Unraveling skeletal muscle senescence in an in vitro cell culture model
Prostaglandin E2 drives cellular senescence and scar fibrosis after cesarean section in mice
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean…Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.
Renal Function, Appendicular Lean Mass, and Bone Stiffness: Indirect Associations Through Fibroblast Growth Factor 21
Altered cell crosstalk marks muscle disuse recovery in older women
At seven days of recovery from disuse, older women exhibited 7,999 differentially expressed genes across muscle cell types compared to 1,548 in…At seven days of recovery from disuse, older women exhibited 7,999 differentially expressed genes across muscle cell types compared to 1,548 in younger women.
Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
ApoD drives cellular aging phenotypes through a nuclear mechanotransduction feedback loop
In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular…In cultured fibroblasts and mice, apolipoprotein D triggers SUN1 accumulation, reinforcing a signaling cycle that alters gene expression and cellular polarity.
Human lymph node fibroblasts show cellular aging features before rheumatoid arthritis onset
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle…Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.