Papers on enzymes

7,064 papers202 new in 30 days

Friday, May 15

Journal of the Science of Food and AgricultureMay 15

Muscle protein fragment extended lifespan in worms

Worms given 5 mmol/L of the peptide Leu-Tyr-Ala lived 26% longer on average than water-treated controls.Worms given 5 mmol/L of the peptide Leu-Tyr-Ala lived 26% longer on average than water-treated controls.

Worm studyMuscle

Paper

Current Topics in Microbiology and ImmunologyMay 15

Resolution of Skeletal Muscle Inflammation: Role of Specialized Pro-resolving Lipid Mediators in the Recovery from Exercise, Injury, and Disease

ReviewInflammation

Paper

npj AgingMay 15

Metal ions in aging and ocular diseases: biology, pathophysiology, and therapeutic strategies

ReviewMechanisms

Paper

Thursday, May 14

Frontiers in NutritionMay 14

Negative impact of reduced exocrine pancreatic function on sarcopenia risk in the asymptomatic general population

Cohort study of 5,598 peopleSarcopenia

Paper

Respiratory InvestigationMay 14

Urinary N-terminal titin fragment as a supplementary marker for frailty in chronic obstructive pulmonary disease

Cross-sectional study of 27 peopleChronic obstructive pulmonary disease

Paper

Wednesday, May 13

Frontiers in Molecular MedicineMay 13

Sirtuin 1 is a key molecular link between cellular senescence and heart failure

ReviewSirtuin signaling

Paper

NutrientsMay 13

Chlorophyll Supplementation Delays Aging in Drosophila melanogaster via Enhanced Stress Resistance and Detoxification Network Remodeling

Experiments in fliesInterventions

Paper

Reproductive ToxicologyMay 13

FSH mediated endocrine disruption potential of Dibutyl phthalate in cultured ovine ovarian granulosa cells: Cytotoxicity, oxidative stress, steroidogenesis, cell senescence, and expression of related key developmental genes

Experiments in cellsOxidative stress and ROS signaling

Paper

INTERNATIONAL JOURNAL OF ENDOCRINOLOGYMay 13

Assessment of the impact of individual modified risk factors on cognitive function and amyloid beta oligomer levels in cerebrospinal fluid in patients with metabolic syndrome

Cohort study of 100 peopleMechanisms

Paper

Tuesday, May 12

Biomedicine & PharmacotherapyMay 12

Dysregulation of the ubiquitin-proteasome system in aging skeletal muscle

ReviewUbiquitin–proteasome system

Paper

Biochemical and Biophysical Research CommunicationsMay 12

Type 2A fibers were richer in mitochondria in mouse muscles

Experiments across mouse muscle regions found higher mitochondrial content in type 2A than type 1 fibers, a pattern maintained during aging and exercise.Experiments across mouse muscle regions found higher mitochondrial content in type 2A than type 1 fibers, a pattern maintained during aging and exercise.

Mouse studyMitochondrion

Paper

Monday, May 11

PNASMay 11

Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes

Experiments in miceEye

Paper

Biology of ReproductionMay 11

O-GlcNAcylation of p66Shc drives senescence-associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†

Experiments in human cellsSenescence-associated secretory phenotype (SASP)

Paper

Developmental PsychobiologyMay 11

Sex-Dependent Effects of Maternal Caloric Restriction, but Not Intermittent Fasting, on Offspring Hippocampal Memory and Antioxidant Activity

Experiments in ratsDietary restriction

Paper

Molecular Biology ReportsMay 11

The common pathological network of inflammation, extracellular matrix imbalance, and senescence in intervertebral disc degeneration and osteoarthritis

ReviewCellular senescence

Paper

CureusMay 11

Impact of Proton Pump Inhibitor Therapy on Bone Mineral Density: An Updated Systematic Review

Systematic review of observational studiesProton-pump inhibitors

Paper

Journal of Orthopaedic Surgery and ResearchMay 11

SENP1 mitigates intervertebral disc degeneration: mechanisms involving suppression of pyroptosis and apoptosis in nucleus pulposus cells

Experiments in ratsPyroptosis

Paper

Meditsinskiy SovetMay 11

Comprehensive approach to managing climacteric syndrome considering new pathogenetic mechanisms: Therapy and prevention

ReviewInterventions

Paper

Sunday, May 10

ToxinsMay 10

Nicotinamide Ameliorates Deoxynivalenol-Induced Injury in Renal Cells via Inhibiting PARP1 Hyperactivation and Restoring NAD⁺ Homeostasis

Experiments in pigsNicotinamide

Paper

Free Radical Biology & MedicineMay 10

FMO1 disrupts mitochondrial functional homeostasis through ROS-mediated mechanisms to drive chondrocyte senescence and hypertrophy

Study in peopleOxidative stress and ROS signaling

Paper

Saturday, May 9

BMC Women's HealthMay 9

Effects of short-term resistance training plus whole-body neuromuscular electrical stimulation on blood cardiometabolic biomarkers in sedentary middle-aged women: a parallel-group, randomized trial

Randomized trial in 23 peopleNeuromuscular electrical stimulation

Paper

Neurobiology of AgingMay 9

Trehalase-trehalose axis in the human brain: A potential modulator of neuroprotection and neurodegeneration

Computational studyMechanisms

Paper

CosmodermaMay 9

The emerging potential of nicotinamide adenine dinucleotide (NAD+) precursors in dermatological health and anti-aging: Elixir of life?

ReviewNAD+ precursors

Paper

Friday, May 8

Angewandte ChemieMay 8

Manganese-Chelating L-Serine Nanoarchitectures: Targeting Kidney Injury Molecule-1 for Reversing Renal Ischemia-Reperfusion Injury via Senescence Regulation

Experiments in animalsKidney

Paper

Communications BiologyMay 8

Calorie restriction eased early memory decline in mice

Male mice with impaired DNA repair showed better learning and memory with food restriction from 8 to 48 weeks, compared with unrestricted feeding.Male mice with impaired DNA repair showed better learning and memory with food restriction from 8 to 48 weeks, compared with unrestricted feeding.

Mouse studyDietary restriction