CD8+ T cell
Biomarker3 papers3 findings
- Humans2
- Animals1
Interventions
1Time-restricted feeding
downin mice1Very low certainty
1 study
Time-restricted feeding
downin mice1Very low certainty
Time-restricted feeding decreases CD8+ T cell in mice.
Animalsin diet-induced obese micekidney2 weeks
Time-restricted feeding reverses kidney fibrosis through reduced CD8+ T cell infiltration in obese mice · JCI insight · 20 Aug 2026
Upstream
1Age
downin humans1
1 study
Age
downin humans1
Age decreases CD8+ T cell in humans.
Humanshealthy adultsperipheral bloodn = 1,760
Establishing Reference Intervals for Adult Lymphocyte Subsets: Single-Platform Volume Analysis Reveals Age- and Sex-Specific Trajectories of Immunosenescence · Journal of immunology research · 1 Jan 2026
Associations
1Tissue damage
upin humans1
1 study
Tissue damage
upin humans1
CD8+ T cell is associated with tissue damage in humans.
“activated CD8+ and tissue‐resident memory T cells associate with basal keratinocyte injury”
Reviewin oral lichen planus
T-cell senescence and immunosenescence in chronic oral mucosal inflammatory diseases: mechanisms and therapeutic implications · Journal of oral microbiology · 27 Sep 2026
Funding
National Institute of Allergy and Infectious DiseasesUS$658.8kNational Cancer InstituteUS$176kNational Institute on AgingUS$47.3k3 grants since 2024
The Role of Peripheral Aged CD8+ T Cells in Hippocampal-Dependent Cognitive Decline
National Institute on AgingUniversity of California, San FranciscoUS$47.3k2024–2027
The effect of aging on cDC1 function and CD8 T cell immunity in tumors
National Cancer InstituteMassachusetts General HospitalUS$176k2025–2027
Naive CD8 T cell functional heterogeneity
National Institute of Allergy and Infectious DiseasesCincinnati Childrens Hosp Med CtrUS$658.8k2025–2030
Latest
30Nicotinamide riboside improves parasite control in mice
In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and…In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle.
T cell KRAS upregulation is linked to premature coronary disease
Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery…Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.
Mitochondrial TFAM limits CD8+ T cell lung damage in mice
In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost…In mice infected with influenza, CD8+ T cells lacking one TFAM copy provoked lung immunopathology without improving viral control and later lost recall immunity.