CD4+ T cells
Biomarker2 papers
- Humans2
Latest
16bioRxivAnimalsPreprint
Senescent CD4 T cells drive age-associated autoimmunity in mice and humans
Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.Targeting senescent immune cells with fisetin or ruxolitinib reduced disease features and protected mice against autoimmune peripheral nerve damage.
Science AdvancesAnimals
SATB1 loss reshapes 3D genome in mouse naive T cells
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene…Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.
International Journal of Molecular SciencesReview
Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians
Nature CommunicationsHumans
Sex-specific trajectories of nonlinear immune aging at single-cell level
Journal of ImmunologyAnimals