Branched-chain amino acids

Biomarker4 papers2 findings

Human trial1
Humans2

Interventions

1

Glimepiride

downin humans1Moderate certainty

1 study

Glimepiride decreases branched-chain amino acids in humans.
Human trialtype 2 diabetes and biopsy-confirmed MASLDliver48 weeks
Distinct metabolomic signatures of SGLT2 inhibitor vs. sulfonylurea in a paired human liver biopsy study · Biochemistry and biophysics reports · 14 Sep 2026

Glimepiride →

Associations

1

Sarcopenic obesity

upin humans1OR 1.555–1.693

1 study

Branched-chain amino acids raise the risk of sarcopenic obesity in humans (ORs: 1.555-1.693, P < 0.01).
Humans14 years
Divergent amino acid profiles in sarcopenic obesity versus non-obese sarcopenia: A prospective cohort study in community-dwelling older adults · The journal of nutrition, health & aging · 11 Sep 2026

Sarcopenic obesity →

Latest

10

NutrientsReview28 Sep

Leucine-Enriched Essential Amino Acids in Clinical Practice: A Narrative Review

BMC Pharmacology & ToxicologyModel organisms26 Sep

Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model

Biochemistry and Biophysics ReportsHuman trial23 Sep

Distinct metabolomic signatures of SGLT2 inhibitor vs. sulfonylurea in a paired human liver biopsy study

The Journal of Nutrition, Health & AgingHumans11 Sep

Divergent amino acid profiles in sarcopenic obesity versus non-obese sarcopenia: A prospective cohort study in community-dwelling older adults

Sarcopenic obesity

Preprints.orgReviewPreprint9 Sep

Gut Microbiome and Gut-Derived Metabolites to Identify the Transition from Metabolically Healthy to Unhealthy Obesity: A Mini Review

GeroScienceModel organisms3 Sep

Intermediate leucine catabolism is associated with longevity and sustained reproduction in grasshoppers

International Journal of SurgeryHumans2 Sep

Temporal changes in circulating metabolites after metabolic and bariatric surgery and risk of incident coronary heart disease: evidence from prospective cohort and nested case-control studies

Coronary heart disease

Frontiers in NeuroscienceHumans29 Aug

Retinal neurovascular coupling dysfunction and plasma metabolomic features as biomarkers of Alzheimer's disease: an integrated diagnostic model

Alzheimer's disease

Frontiers in EndocrinologyHumans29 Aug

A distinct serum metabolic profile characterizes osteosarcopenia: identifying potential metabolic biomarkers

Osteosarcopenia

LifeHuman trial27 Aug

Effects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial