Leucine

Biomarker3 papers3 findings

Humans2

Associations

Neurovascular coupling index

upin humans1

1 study

Leucine is associated with neurovascular coupling index in humans (r = 0.205, q = 0.0011).
Humansin individuals with AD, MCI, and controls
Retinal neurovascular coupling dysfunction and plasma metabolomic features as biomarkers of Alzheimer's disease: an integrated diagnostic model · Frontiers in neuroscience · 14 Aug 2026

Neurovascular coupling index →

Alzheimer's disease

downin humans1

1 study

Alzheimer's disease is associated with leucine in humans (-17.0%, P < 0.001).
HumansAD vs controls
Retinal neurovascular coupling dysfunction and plasma metabolomic features as biomarkers of Alzheimer's disease: an integrated diagnostic model · Frontiers in neuroscience · 14 Aug 2026

Alzheimer's disease →

Osteosarcopenia

upin humans1

1 study

Leucine predicts osteosarcopenia in humans (AUC 0.79).
Humansdistinguishing osteosarcopenia from osteoporosisserum
A distinct serum metabolic profile characterizes osteosarcopenia: identifying potential metabolic biomarkers · Frontiers in endocrinology · 14 Aug 2026

Osteosarcopenia →

Funding

National Institute on AgingUS$514.4k1 grant since 2023

Sestrins-mediated integration of leucine and exercise benefits for mitochondrial homeostasis
National Institute on AgingUniversity of Michigan at Ann ArborUS$514.4k2023–2028

Latest

NutrientsReview28 Sep

Leucine-Enriched Essential Amino Acids in Clinical Practice: A Narrative Review

Interventions

Iranian Journal of Medical SciencesAnimals21 Sep

Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats

Interventions

Preprints.orgHuman trialPreprint16 Sep

Effects of Body-Mass-Scaled Protein and Leucine Supplementation on Body Composition and Cardiometabolic Blood Markers during Weight Loss in Older Men—A Randomized Controlled Trial

Interventions

Frontiers in NutritionReview11 Sep

Comparative effects of pea protein vs. dairy proteins (α-lactalbumin and casein) on aminoacidemia, exercise performance, gut microbiota, hormonal responses, neurocognitive function, mood, and metabolic-inflammatory responses in older adults

Interventions

Frontiers in NutritionReview9 Sep

Comparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis

Resistance training

Acta HistochemicaHumans3 Sep

Reduced number of epithelial tuft cells and density of LGR5 expression in the myenteric plexus of the ageing human colon

Gut and microbiome

GeroScienceModel organisms3 Sep

Intermediate leucine catabolism is associated with longevity and sustained reproduction in grasshoppers

Interventions

Movement DisordersHumans2 Sep

The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-Onset Parkinson's Disease

Parkinson's disease

Frontiers in NeuroscienceHumans29 Aug

Retinal neurovascular coupling dysfunction and plasma metabolomic features as biomarkers of Alzheimer's disease: an integrated diagnostic model

Alzheimer's disease

Frontiers in EndocrinologyHumans29 Aug

A distinct serum metabolic profile characterizes osteosarcopenia: identifying potential metabolic biomarkers

Osteosarcopenia

Leucine

Associations

Funding

Latest

Related