DICER1
4 papers4 findings
- 2 independent labs in 2 countries
- Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 7 more
- Humans1
- Animals2
- Model organisms1
Interventions
2Methionine restriction
upin mouse cells1
1 study
Methionine restriction
upin mouse cells1
Methionine restriction increases DICER1 in mouse cells.
“sulfur amino acid restriction (i.e., methionine or cysteine) is sufficient to increase Dicer mRNA expression in preadipocytes.”
Cellspreadipocytes
Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects
Molecular metabolism28 Aug 2019
Caloric restriction
downin mice1
1 study
Caloric restriction
downin mice1
Caloric restriction prevents DICER1 in mice.
“This is prevented in both species by caloric restriction.”
Animalsadipose tissue
Role of microRNA processing in adipose tissue in stress defense and longevity
Cell metabolism5 Sep 2012
Effects
2UCP1
upin mice1
1 study
UCP1
upin mice1
DICER1 increases UCP1 in mice.
“In mice, DICER plays a role in methionine restriction-induced upregulation of Ucp1 in adipose tissue.”
Animalsadipose tissue
Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects
Molecular metabolism28 Aug 2019
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
DICER1 protects against cellular senescence in cells.
“Knockdown of Dicer in cells results in premature senescence”
Cellsshown by knockdown
Role of microRNA processing in adipose tissue in stress defense and longevity
Cell metabolism5 Sep 2012