Papers on bone resorption

529 papers27 new in 30 days

Monday, October 26

Diabetes/metabolism Research and ReviewsOct 26

Exercise Modulates the Osteoimmune Axis: Myokine-Mediated Mechanisms in Diabetic Bone Disease

ReviewExercise

Paper

Sunday, October 25

Materials Today BioOct 25

Targeted RNA delivery alleviates bone loss in mice

In a mouse model of osteoporosis caused by ovary removal, bone-targeted engineered vesicles preserved bone structure and reduced bone-breakdown activity without causing…In a mouse model of osteoporosis caused by ovary removal, bone-targeted engineered vesicles preserved bone structure and reduced bone-breakdown activity without causing systemic toxicity.

Mouse studyBones and joints

Paper

Bioactive MaterialsOct 25

Targeted RNA-carrying particles reduced bone loss in mice

In an experiment in mice with ovaries removed, targeted particles restored spongy bone structure and bone strength.In an experiment in mice with ovaries removed, targeted particles restored spongy bone structure and bone strength.

Mouse studyBones and joints

Paper

Food & FunctionOct 25

Heat-treated gut bacteria reduced bone loss in rats

An experiment in rats with their ovaries removed found reduced bone breakdown, better intestinal barriers and less inflammation in the colon.An experiment in rats with their ovaries removed found reduced bone breakdown, better intestinal barriers and less inflammation in the colon.

Dense and fragile bone cross-sections sit beside a rat, above intact intestinal lining with few immune cells and broken lining crowded with immune cells.

Rat studyBone loss

Paper

Saturday, October 24

Archives of OsteoporosisOct 24

Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review

Systematic review of randomized trialsGLP-1 receptor agonists

Paper

Journal of Agricultural and Food ChemistryOct 24

Cyclovirobuxine Prevents Osteoclastogenesis and Estrogen Deficiency-Induced Bone Loss by Inhibiting ROS Generation via the PI3K/AKT/FOXO1 Pathway

Experiments in mouse cellsBone loss

Paper

Friday, October 23

Journal of Translational MedicineOct 23

Packages from immature bone-forming cells reduced bone loss in mice

In a mouse experiment, injections of packages released by immature bone-forming cells improved bone structure after ovary removal.In a mouse experiment, injections of packages released by immature bone-forming cells improved bone structure after ovary removal.

Mouse studyBones and joints

Paper

Tuesday, October 20

Frontiers in EndocrinologyOct 20

The incretin-bone axis: molecular mechanisms and clinical implications

Effects of incretin hormones on bone cells.

ReviewGLP-1 and incretin signaling

Paper

Saturday, October 17

Frontiers in NeuroendocrinologyOct 17

Depression and bone loss: associations, skeletal features and mechanisms from clinical and preclinical studies

ReviewBones and joints

Paper

Friday, October 16

Research SquareOct 16

Riociguat Suppresses Osteoclastogenesis and Ovariectomy-Induced Bone Loss by Attenuating MAPK Signaling and PPARγ–PGC-1β Coupling

Preprint: experiments in miceBone loss

Paper

Thursday, October 15

Drug Design, Development and TherapyOct 15

Managing Rebound Bone Loss After Denosumab Discontinuation: Mechanisms, Risk Stratification, and Sequential Therapy

ReviewDenosumab

Paper

Wednesday, October 14

Journal of Dental ResearchOct 14

GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence Gaps

ReviewGLP-1 receptor agonists

Paper

Frontiers in ImmunologyOct 14

Gut microbiota-mediated Th17/Treg regulation in osteoporotic fracture: from postmenopausal dysbiosis to callus repair

$Proposed mechanism linking gut dysbiosis to impaired fracture repair in postmenopausal osteoporosis.$

ReviewMicrobiome composition

Paper

Monday, October 12

Advanced ScienceOct 12

Drug-carrying particles reduced bone loss in mice

In an animal experiment, drug-carrying particles preserved bone structure and enhanced bone formation in mice whose ovaries had been removed.In an animal experiment, drug-carrying particles preserved bone structure and enhanced bone formation in mice whose ovaries had been removed.

Experiments in miceBones and joints

Paper

Sunday, October 11

Journal of Orthopaedic SurgeryOct 11

Glaucoma eye-drop groups differed in osteoporosis risk

Osteoporosis was diagnosed in 13.3% of patients prescribed drops such as latanoprost, compared with 8.9% prescribed drops such as pilocarpine.Osteoporosis was diagnosed in 13.3% of patients prescribed drops such as latanoprost, compared with 8.9% prescribed drops such as pilocarpine.

A large dark blue-green thigh bone with sparse internal struts stands beside a smaller, denser gray bone, each near an eye with a droplet above it.

Cohort study of 6,743 peoplePrimary open-angle glaucoma

Paper

Saturday, October 10

Research SquareOct 10

Loss of a matrix enzyme triggers adult bone loss in mice

Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.

Porous bone with sparse bone-forming cells and clustered immune cells stands beside a denser bone fragment and a laboratory mouse.

Preprint: experiments in miceBones and joints

Paper

Thursday, October 8

Scientific ReportsOct 8

Copper-binding protein deficiency linked to higher bone mass in mice

Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.Experiments in mice whose ovaries had been removed linked ceruloplasmin deficiency to higher bone mass at the tissue level.

Experiments in cellsBones and joints

Paper

Wednesday, October 7

Nature CommunicationsOct 7

Targeting a cell regulator reduced bone loss in mice

In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.In a mouse model of osteoporosis, silencing a gene or inhibiting its protein reduced the activity of cells that break down bone.

Oxr1 is upregulated during osteoclast differentiation and osteoporosis pathogenesis.

Experiments in miceBones and joints

Paper

Wednesday, September 30

Advanced Healthcare MaterialsSep 30

Coated implants improved bone attachment in osteoporotic rats

A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.A titanium surface promoted bone formation around implants and improved spongy bone structure in an experiment in rats with age-related osteoporosis.

Experiments in ratsBones and joints

Paper

Nutrition and HealthSep 30

A comprehensive review on osteoporosis in women and beneficial effects of antioxidants on osteoporosis: A systematic review

Systematic reviewAntioxidants

Paper

Tuesday, September 29

Preprints.orgSep 29

Nutrition-Derived Bioactive Polyphenolic Metabolites Produced by Gut Microbiota and Their Potential Impact on Bone Health in Humans

Preprint: reviewBones and joints

Paper

Experimental PhysiologySep 29

Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Bone and muscle markers altered during bedrest and addressed in this review.

ReviewBones and joints

Paper

Monday, September 28

Advanced ScienceSep 28

Puerarin-loaded nanoparticles improve bone mass in mice

In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.In ovariectomized mice, six weeks of treatment with pH-responsive puerarin nanoparticles restored trabecular bone architecture and increased bone mineral density.

Experiments in miceBones and joints

Paper

Advanced MaterialsSep 28

Bone-targeted exosomes delivering betaine reverse bone loss in osteoporotic rats

The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.The engineered delivery vehicle enhances autophagy in senescent stem cells and suppresses osteoclast activity to restore bone metabolic homeostasis.