3 papers1 finding
Farnesyl pyrophosphate
downin mice1
Farnesyl pyrophosphate decreases aneuploidy in mice.
“promoting cortical F-actin reassembly and reducing aneuploidy of aged oocytes.”
Animalsoocytefemales
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases
Nature aging26 Aug 2025
An analysis of one donor’s melanoma found 16% of acquired DNA variants in sequences absent from a conventional human reference genome.An analysis of one donor’s melanoma found 16% of acquired DNA variants in sequences absent from a conventional human reference genome.
Limit: Only one donor’s melanoma was analysed
A large genomic analysis reveals over 800 inherited variants and structural features that alter how frequently chromosomes missegregate in aging individuals.A large genomic analysis reveals over 800 inherited variants and structural features that alter how frequently chromosomes missegregate in aging individuals.
In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.