Adhesion molecule expression

1. Evogliptin decreases adhesion molecule expression in mouse cells (TNF-α-stimulated endothelial cells).

   “In the endothelial cells, evogliptin inhibited inflammatory responses via suppression of adhesion molecules induced by TNF-α.”

   CellsTNF-α-stimulated endothelial cells

   Modulation of Sirt1/NF-κB interaction of evogliptin is attributed to inhibition of vascular inflammatory response leading to attenuation of atherosclerotic plaque formation

   Biochemical pharmacology·Aug 14, 2019

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1. ARG-II is required for adhesion molecule expression in human cells (TNF-α-stimulated HK-2 proximal tubular cells).

   “In human proximal tubular cells (HK-2), TNF-α enhances adhesion molecule expression dependently on Arg-II upregulation.”

   CellsTNF-α-stimulated HK-2 proximal tubular cells

   Role of tubular epithelial arginase-II in renal inflammaging

   NPJ aging and mechanisms of disease·Mar 2, 2021

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