There is 1 paper on ARG-II in aging research: none in people yet, 1 in animals.
1 paper studies it3 findings
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Science Foundation and 2 more
- Animals1
Effects
3TGFβ1
upin human cells1
1 study
TGFβ1
upin human cells1
ARG-II increases TGFβ1 in human cells (HK-2 cells overexpressing Arg-II; prevented by mitochondrial ROS inhibition).
“Overexpression of Arg-II in the cells enhances TGFβ1 levels which is prevented by mitochondrial ROS inhibition.”
CellsHK-2 cells overexpressing Arg-II; prevented by mitochondrial ROS inhibition
Role of tubular epithelial arginase-II in renal inflammaging
NPJ aging and mechanisms of disease
Adhesion molecule expression
is required forin human cells1
1 study
Adhesion molecule expression
is required forin human cells1
ARG-II is required for adhesion molecule expression in human cells (TNF-α-stimulated HK-2 proximal tubular cells).
“In human proximal tubular cells (HK-2), TNF-α enhances adhesion molecule expression dependently on Arg-II upregulation.”
CellsTNF-α-stimulated HK-2 proximal tubular cells
Role of tubular epithelial arginase-II in renal inflammaging
NPJ aging and mechanisms of disease
Renal inflammaging and tubulointerstitial fibrosis
upin mice1
1 study
Renal inflammaging and tubulointerstitial fibrosis
upin mice1
ARG-II increases renal inflammaging and tubulointerstitial fibrosis in mice (arg-II knockout versus wild-type mice; effect predominant in females).
“This renal aging phenotype is significantly suppressed in arg-II-/- mice, mainly in the females in which Arg-II level is higher than in the males.”
Animalsarg-II knockout versus wild-type mice; effect predominant in femaleskidney
Role of tubular epithelial arginase-II in renal inflammaging
NPJ aging and mechanisms of disease