Aβ aggregation

1. Matrine decreases Aβ aggregation in worms.

   “matrine not only reduces Aβ aggregation but also alleviates Aβ-mediated lipid metabolic disorder”

   Model organismsin an Alzheimer's disease C. elegans model

   Matrine Inhibits High-Glucose-Diet-Induced Fat Accumulation and Aβ-Mediated Lipid Metabolic Disorder via AAK-2/NHR-49 Pathway in Caenorhabditis elegans

   International journal of molecular sciences·26 Mar 2025

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1. Ktp@mno2 decreases Aβ aggregation in worm cells (100% inhibition at 50 μg/mL).

   “increased from 18%, 33%, and 49% (10, 25, and 50 μg/mL TTR, respectively) to 52%, 81%, and 100% (10, 25, and 50 μg/mL KTP@MnO2)”

   Cellsin vitro50 μg/mL

   Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis

   Molecules (Basel, Switzerland)·21 Mar 2024

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