Ktp@mno2

1. Ktp@mno2 extends lifespan in worms (+7 d).

   “and extended their lifespan by 7 d”

   Model organismsAD nematodes50 μg/mL

   Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis

   Molecules (Basel, Switzerland)·21 Mar 2024

1. Ktp@mno2 decreases amyloid plaques in worms (completely cleared).

   “completely cleared amyloid plaques in AD nematodes”

   Model organismsAD nematodes50 μg/mL

   Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis

   Molecules (Basel, Switzerland)·21 Mar 2024

More on Amyloid plaques

1. Ktp@mno2 improves cell viability in worm cells (from 66% to more than 95%).

   “KTP@MnO2 at 50 μg/mL increased the viability of Aβ-treated cells from 66% to more than 95%”

   CellsAβ-treated cells50 μg/mL

   Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis

   Molecules (Basel, Switzerland)·21 Mar 2024

1. Ktp@mno2 decreases Aβ aggregation in worm cells (100% inhibition at 50 μg/mL).

   “increased from 18%, 33%, and 49% (10, 25, and 50 μg/mL TTR, respectively) to 52%, 81%, and 100% (10, 25, and 50 μg/mL KTP@MnO2)”

   Cellsin vitro50 μg/mL

   Composite of KLVFF-Transthyretin-Penetratin and Manganese Dioxide Nanoclusters: A Multifunctional Agent against Alzheimer's β-Amyloid Fibrillogenesis

   Molecules (Basel, Switzerland)·21 Mar 2024

More on Aβ aggregation