TTR
Gene6 papers2 findingsHGNC 12405NCBI Gene 7276Taxon 9606
- Humans3
- Animals2
Effects
1Clathrin-mediated endocytosis
downin mice1
1 study
Clathrin-mediated endocytosis
downin mice1
TTR decreases clathrin-mediated endocytosis in mice.
“Functional studies demonstrated that TTR contributes to maintaining BBB integrity by promoting endothelial homeostasis and limiting endothelial endocytosis”
Animalsin endothelial cellshippocampus
Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer's Disease · bioRxiv · 4 Sep 2026 · Preprint
Upstream
1Alzheimer's disease
downin human cells1
1 study
Alzheimer's disease
downin human cells1
Alzheimer's disease decreases TTR in human cells.
“was accompanied by reduced vascular TTR expression in human AD brains.”
Cellsin human AD brainsbrain
Transthyretin Contributes to Hippocampal Blood-Brain Barrier Recovery Following Intestinal Inflammation, with Reduced Expression in Alzheimer's Disease · bioRxiv · 4 Sep 2026 · Preprint
Funding
National Heart, Lung, and Blood InstituteUS$1.4m2 grants since 2022
National Heart, Lung, and Blood InstituteUT Southwestern Medical CenterUS$692.7k2022–2027
National Heart, Lung, and Blood InstituteUT Southwestern Medical CenterUS$659.5k2025–2029