David Andrew Sinclair
Harvard University
Also published as: D A Sinclair, David Sinclair, David A. Sinclair
119 papersORCID 0000-0002-9936-436XOpenAlex
Harvard Medical School · Life Biosciences · MetroBiotech
- Sirtuin signaling
- NAD+ metabolism
- Mitochondrion
- SIRT1
- Inflammation
- Nicotinamide mononucleotide
- Epigenetic regulation of gene expression
- Resveratrol
Papers
Research Square
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
Preprint: experiments in miceNicotinamide mononucleotide
The Journals of Gerontology, Series A
The association of frailty with age and lifespan in mice differs by strain and sex
Study of 1,564 miceBiomarkers
Frontiers in Genetics
Turning back time: a comprehensive list of interventions that decrease next-generation epigenetic aging clocks in humans
Systematic reviewInterventions
Progress in Retinal and Eye Research
Epigenetic reprogramming for ocular aging and disease: Mechanisms, biomarkers, and the road to the clinic
ReviewInterventions
Asia-Pacific Journal of Ophthalmology
Oculomics and AI: The eye as a biomarker for health span
ReviewBiomarkers
bioRxiv
DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice
Preprint: experiments in animalsBiomarkers
bioRxiv
DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer's Disease Mouse Model
Preprint: experiments in animalsMechanisms
bioRxiv
Chemotherapy accelerated bone ageing is reversed by NMN
Preprint: experiments in animalsNicotinamide mononucleotide
The Journals of Gerontology, Series A
Multiomic clocks to predict phenotypic age in mice
Experiments in miceBiomarkers
bioRxiv
Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision
Preprint: experiments in miceEye
bioRxiv
Guided multi-agent AI invents highly accurate, uncertainty-aware transcriptomic aging clocks
Preprint: computational studyBiomarkers
Circulation Research
Single-Short Partial Reprogramming of the Endothelial Cells Decreases Blood Pressure via Attenuation of EndMT in Hypertensive Mice
Experiments in miceHypertension
npj Aging
Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice
Experiments in miceBiomarkers
Cell Reports
Cellular rejuvenation protects neurons from inflammation-mediated cell death
Study in peopleInterventions
Biology of Sex Differences
Sex dimorphism and tissue specificity of gene expression changes in aging mice
Experiments in miceMechanisms
EMBO Molecular Medicine
Fertility protection during chemotherapy treatment by boosting the NAD(P)⁺ metabolome
Experiments in miceReproductive system
bioRxiv
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
Preprint: experiments in miceNicotinamide mononucleotide
Nature Aging
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction
Study of 1,800 peopleEpigenetic clock
Cellular Reprogramming
Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma
Experiments in miceGlaucoma
Aging Cell
SIRT2 transgenic over-expression does not impact lifespan in mice
Experiments in miceInterventions
Journal of Neuro-ophthalmology
The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy
ReviewEye
FEBS Letters
Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
Experiments in animalsNicotinamide mononucleotide
Aging
Chemically induced reprogramming to reverse cellular aging
Experiments in human cellsInterventions
The Journal of Clinical Endocrinology and Metabolism
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
Randomized trial in 30 peopleOverweight
Journal of Medicinal Chemistry
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
Experiments in cellsMechanisms
Molecular Biology and Evolution
Sirtuin Evolution at the Dawn of Animal Life
Computational studySirtuin signaling
PLOS Computational Biology
Novel feature selection methods for construction of accurate epigenetic clocks
Computational studyEpigenetic clock
The Journals of Gerontology, Series A
Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy
Experiments in miceBiomarkers
Nature Reviews Endocrinology
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
ReviewMitochondrion
Journal of Acquired Immune Deficiency Syndromes
Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults
Study in peopleMechanisms
bioRxiv
TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions
Preprint: study in peopleBiomarkers
Nutrients
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice
Experiments in miceGut and microbiome
Nature
Reprogramming to recover youthful epigenetic information and restore vision
Experiments in animalsInterventions
The Journals of Gerontology, Series A
Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet
Experiments in miceMetformin
Preprint
Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome
Preprint: experiments in animalsInterventions
Nature Communications
Age and life expectancy clocks based on machine learning analysis of mouse frailty
Experiments in miceBiomarkers
Cell Reports
NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging
Experiments in animalsInterventions
bioRxiv
DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
Preprint: experiments in animalsMechanisms
AIDS Research and Human Retroviruses
Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research
ReviewIndustry & policy
bioRxiv
NAD + repletion rescues female fertility during reproductive ageing
Preprint: experiments in animalsInterventions
bioRxiv
Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming
Preprint: experiments in animalsInterventions
Free Radical Biology & Medicine
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
ReviewMechanisms
Current Opinion in Physiology
Sex differences in the response to dietary restriction in rodents
ReviewInterventions
Reproduction
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice
Experiments in animalsInterventions
Mechanisms of Ageing and Development
Frailty biomarkers in humans and rodents: Current approaches and future advances
ReviewBiomarkers
Cell Metabolism
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
Experiments in animalsInterventions
Critical Reviews in Biochemistry and Molecular Biology
Epigenetic changes during aging and their reprogramming potential
ReviewMechanisms
Methods in Molecular Biology
Molecular and Cellular Characterization of SIRT1 Allosteric Activators
Study protocolSirtuin signaling
Pharmacology & Therapeutics
Sirtuin activators and inhibitors: Promises, achievements, and challenges
ReviewInterventions
Cell Metabolism
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
Experiments in miceNAD+ precursors
Human Reproduction Open
Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide
Experiments in animalsInterventions
Molecular Metabolism
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
Experiments in animalsInterventions
Science
A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging
Experiments in animalsMechanisms
The Journals of Gerontology, Series A
Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults
Randomized trial in 30 peopleResveratrol
Cell Death and Differentiation
SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation
Experiments in animalsMechanisms
Metabolic Syndrome and Related Disorders
Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease
ReviewInterventions
Cell Metabolism
NAD⁺ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Experiments in miceInterventions
Nature Reviews Molecular Cell Biology
Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds
ReviewInterventions
Frontiers in Pharmacology
Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice
Experiments in animalsInterventions
Cell Metabolism
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Experiments in miceInterventions
Mechanisms of Ageing and Development
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Experiments in wormsFOXO signaling
Aging Cell
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Experiments in miceBones and joints
The EMBO Journal
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
Experiments in miceInterventions
Cell Reports
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
Experiments in miceInterventions
Haematologica
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
Experiments in animalsResveratrol
The Journals of Gerontology, Series A
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
Experiments in miceCurcumin
Works at
Professor
Sources: reporter.nih.gov
Founded
Board chairman
Sources: lifebiosciences.com
Advises
Scientific Advisory Board
Sources: metrobiotech.com
Protocols
David Sinclair's daily regimen in Lifespan
Lifespan: Why We Age, and Why We Don't Have To (2019)
Sources: lifespanbook.com
Grants and prizes
R01, Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks, R01AG082737, 2023–2028, Jun 8, 2026
R01, Role of epigenetic decay in cell senescence and aging, R01AG019719, 2001–2023, Jan 21, 2022
National Human Genome Research Institute
R21, Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement, R21HG011850, 2021–2023, Sep 17, 2021
R37, SIRT1 as a regulator of health and lifespan of mammals, R37AG028730, 2007–2023, Mar 18, 2021
National Institute of Dental and Craniofacial Research
R21, Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis, R21DE027490, 2018–2020, Jul 5, 2019
Sources: reporter.nih.gov
Earlier work
- ZenodoPreprint2026
JAX-Powered Differentiable Pairwise Relaxation for Fast Geometric Screening of Chiral Carbon Nanotubes, with companion python code
- bioRxivPreprint2026
immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse
- Nature Aging2026
Past, present and future perspectives on the science of aging
- Cell Reports2026
JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks