Chloroquine

Intervention Approved 1949

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
93 trials, 53 with no results posted

1 of 1 finding with company ties

Humans1

Associations

Alzheimer's disease

downin humans1RR 0.56

1 study

Chloroquine lowers the risk of Alzheimer's disease in humans (RR = 0.56, 95% CI: 0.55-0.58).
Humansin claims database validation
Sex- and APOE-specific transcriptomic drug repurposing identifies four candidate therapeutics for Alzheimer's disease
Alzheimer's & dementia (New York, N. Y.)22 Aug 2026

Trials

Approved

FDA Aralen, Aralen Hydrochloride
31 Oct 1949Discontinued

In trials

Malaria
Phase 4Results posted30 trials
Vivax Malaria
Phase 4Completed18 trials
Falciparum Malaria
Phase 4Completed17 trials
COVID-19
Phase 4Completed8 trials
Recurrence
Phase 4Completed4 trials
Glucosephosphate Dehydrogenase Deficiency
Phase 4Terminated3 trials

All 32

Pneumonia
Phase 4Completed2 trials
Rheumatoid arthritis
Phase 4Results posted2 trials
Asthma
Phase 4Completed1 trial
Chronic obstructive pulmonary disease
Phase 4Completed1 trial
Diarrhea
Phase 4Completed1 trial
Hepatitis C
Phase 4Completed1 trial
Hypertension
Phase 4Completed1 trial
Knee osteoarthritis
Phase 4Completed1 trial
Coronavirus infection
Phase 3Completed3 trials
Glioblastoma
Phase 3Completed3 trials
Viral pneumonia
Phase 3Completed2 trials
HIV infection
Phase 2/3Terminated2 trials
Breast neoplasm
Phase 2Status unknown2 trials
Atrial fibrillation
Phase 2Recruiting1 trial
Brain neoplasms
Phase 2Terminated1 trial
Human influenza
Phase 2Status unknown1 trial
Multiple myeloma
Phase 2Terminated1 trial
Neoplasm metastasis
Phase 2Terminated1 trial
Systemic lupus erythematosus
Phase 2Terminated1 trial
Cholangiocarcinoma
Phase 1/2Completed1 trial
Glioma
Phase 1/2Completed1 trial
Infection
Phase 1Completed1 trial
Latent tuberculosis
Phase 1Status unknown1 trial
Neoplasm
Phase 1Completed1 trial
Pancreatic neoplasms
Phase 1Completed1 trial
Small cell lung carcinoma
Phase 1Terminated1 trial

Readouts due

14 May 2027
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
Phase 3Recruiting

Stopped

NCT03337152TerminatedVivax Malaria
study met study halting rules
NCT00308620TerminatedHIV infection
Insufficient financial support; lack of efficacy for primary endpoint
NCT01894633TerminatedBrain neoplasms
terminated
NCT01438177TerminatedMultiple myeloma
PI left institution.
NCT01946880TerminatedSystemic lupus erythematosus
Slow enrollment.
NCT01575782TerminatedSmall cell lung carcinoma
Poor accrual