Valine

Valine has been studied in 5 papers since 1999: 2 observational studies in people, 2 in animals, 1 review; 2 in the past year. It is an approved medicine. The newest story, Oct 22, 2026: “Low-valine diet eases heart enlargement in male rodents”.

Intervention Approved 1984

5 papers study it143 more mention it1 findingUpdated Oct 21, 2026

PubChem ChEBI

“a meta-analysis combined with findings from the National Health and Nutrition Examination Survey (NHANES) indicated a positive association between elevated cardiovascular risk and cumulative dietary valine intake.”

Low-valine diet ameliorates pathological cardiac hypertrophy by inhibiting LONP1-mediated degradation of ATP5F1B in male rodentsNature communications2026doi:10.1038/s41467-026-78676-6

2 of its findings point the other way.

2 independent labs in 1 country
2 findings against
3 trials, 1 about aging

Humans2
Animals2

What did lifespan studies of Valine find?

DrugAge

DrugAge records 3 results from 1 paper: 3 in C. elegans. Average lifespan is the mean or the median, as each paper reports it.

What is Valine linked with?

Studies link Valine with 1 measure, most often cardiovascular disease (1 study).

Cardiovascular disease

upin humans1

1 study

Valine is associated with cardiovascular disease in humans.
“a meta-analysis combined with findings from the National Health and Nutrition Examination Survey (NHANES) indicated a positive association between elevated cardiovascular risk and cumulative dietary valine intake.”
Humans
Low-valine diet eases heart enlargement in male rodents
Nature communicationsOct 21, 2026

Has Valine been tested in people?

1 about aging, of 3

Yes: 2 observational studies in people have been published, and 3 trials are registered.

About aging

NCT07437053
Early phase 1Not yet recruiting

Approved

FDA Trophamine 10%, Trophamine
Jul 20, 1984burns
FDA Travasol 10% IN Plastic Container, Travasol 5.5% IN Plastic Container, Travasol 8.5% IN Plastic Container
Aug 23, 1984TRAVASOL is indicated as a source of amino acids for patients requiring parenteral nutrition when oral or enteral nutrition is not…
FDA Aminosyn-PF 7%
Sep 6, 1985burns
FDA Aminosyn-PF 10%
Oct 17, 1986burns
FDA Aminosyn II 10% IN Plastic Container
Dec 19, 1991stress
FDA Aminosyn II 15% IN Plastic Container
Dec 19, 1991stress

Repurposing

Muscular atrophy
Phase 2Results posted1 trial
Fatigue
Early phase 1Completed1 trial
Chronic kidney failure
Early phase 1Completed1 trial

Trial sponsors

University of Oregon
1 trialPhase 280 people
UT Health San Antonio
1 trialEarly phase 120 people

Latest

25 papers in 12 months

Nature CommunicationsOct 22

Low-valine diet eases heart enlargement in male rodents

In hypertensive male rodents, restricting the dietary amino acid valine improved heart function and reduced harmful muscle enlargement by protecting a key mitochondrial…In hypertensive male rodents, restricting the dietary amino acid valine improved heart function and reduced harmful muscle enlargement by protecting a key mitochondrial protein.

Animal studyInterventions