Glycine

  • 1 lab in 1 country
  • Funders: Key Research and Development Program of Heilongjiang and 4 more
  • Animals3

Outcomes

6

Muscle fiber density

upin rats1

1 study
  1. Glycine increases muscle fiber density in rats.

    “increased muscle fiber density”

    Animalsmuscle

    Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

    Free radical biology & medicine27 Jan 2026

Hepatic cell architecture

upin rats1

1 study
  1. Glycine improves hepatic cell architecture in rats.

    “restored hepatic cell architecture”

    Animalsliver

    Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

    Free radical biology & medicine27 Jan 2026

Hippocampal neuronal damage

downin rats1

1 study
  1. Glycine decreases hippocampal neuronal damage in rats.

    “In aged rats, Gly also upregulated Mthfd2 (the mammalian ortholog of Nmdmc) and reduced neuronal damage in the hippocampus”

    Animalshippocampus

    Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

    Free radical biology & medicine27 Jan 2026

Nmdmc expression

upin flies1

1 study
  1. Glycine increases Nmdmc expression in flies.

    “Gly dose-dependently upregulated the expression of Nmdmc”

    Model organisms

    Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

    Free radical biology & medicine27 Jan 2026

More on Nmdmc expression

Lifespan

upin flies1

1 study
  1. Glycine extends lifespan in flies.

    “In fruit flies, Gly extended lifespan and ameliorating aging-related phenotypes”

    Model organisms

    Glycine ameliorates aging-related dysfunctions associated with Nmdmc-mediated mitochondrial one-carbon metabolism

    Free radical biology & medicine27 Jan 2026

Oxidative stress and ROS signalling

downin reviews1

1 study
  1. Glycine decreases oxidative stress and ROS signalling.

    “Glycine enhances glutathione synthesis and mitigates oxidative and inflammatory damage.”

    Review

    Amino acid metabolism modulates chronic kidney disease progression by mediating the aging process: Mechanistic insights and therapeutic interventions

    Diabetes, obesity & metabolism7 Jan 2026

More on Oxidative stress and ROS signalling

Funding

1 grant since 2023

National Institute on AgingUS$1.2m

Latest

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