Triclosan

1. Triclosan induces cellular senescence in mice.

   “bioenergetic deficit triggered excessive reactive oxygen species (ROS) production, promoting lipid peroxidation and exacerbating cardiomyocyte ferroptosis, cellular senescence, and the senescence-associated secretory phenotype (SASP).”

   Animalsin cardiomyocytes under hypoxia and triclosan exposure

   Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1α-mediated mitochondrial dysfunction to senescence and ferroptosis

   Redox biology·12 Jan 2026

More on Cellular senescence

1. Triclosan increases ventricular remodeling in mice.

   “Exposure to environmentally relevant TCS concentrations dose-dependently aggravated short- and long-term post-MI cardiac dysfunction and ventricular remodeling in both male and female mice.”

   Animalspost-myocardial infarction

   Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1α-mediated mitochondrial dysfunction to senescence and ferroptosis

   Redox biology·12 Jan 2026

1. Triclosan impairs cardiac function in mice.

   “Exposure to environmentally relevant TCS concentrations dose-dependently aggravated short- and long-term post-MI cardiac dysfunction and ventricular remodeling in both male and female mice.”

   Animalspost-myocardial infarction

   Triclosan exacerbates post-myocardial infarction injury via Nur77 ubiquitination: Linking NTRK2/PGC-1α-mediated mitochondrial dysfunction to senescence and ferroptosis

   Redox biology·12 Jan 2026

1. Triclosan inhibits insulin/IGF-1 signalling in human cells.

   “triclosan induces muscle senescence and oxidative stress by inhibiting the IGF-1/Akt/mTOR signaling pathway.”

   Cells

   Triclosan exposure exacerbates muscle wasting via senescence and IGF-1 pathway suppression: A combined epidemiological and experimental study

   Ecotoxicology and environmental safety·3 Oct 2025

More on Insulin/IGF-1 signalling

1. Triclosan increases muscle wasting in human cells.

   “triclosan accelerates muscle wasting through oxidative imbalance and muscle senescence.”

   Cells

   Triclosan exposure exacerbates muscle wasting via senescence and IGF-1 pathway suppression: A combined epidemiological and experimental study

   Ecotoxicology and environmental safety·3 Oct 2025

More on Muscle wasting

1. Triclosan is associated with appendicular skeletal muscle mass index in humans (β = -0.18, 95 % CI (-0.35, -0.01)).

   “individuals in the highest quartile of urinary creatinine-corrected triclosan levels exhibited a 0.18 kg/m2 reduction in appendicular skeletal muscle mass index (ASMI) [β = -0.18, 95 % CI (-0.35, -0.01)]”

   Humansn = 2,878

   Triclosan exposure exacerbates muscle wasting via senescence and IGF-1 pathway suppression: A combined epidemiological and experimental study

   Ecotoxicology and environmental safety·3 Oct 2025

More on Appendicular skeletal muscle mass index