Methylparaben

1. Methylparaben has no effect on melanoma in humans.

   “whereas no significant associations were observed for melanoma”

   Humans

   Association between urinary paraben concentrations and skin cancer among US Adults

   Cancer epidemiology·17 Aug 2026

More on Melanoma

1. Methylparaben increases oxidative damage in flies.

   “and elevated oxidative damage (↑MDA, ↓FRAP) in a dose-dependent manner.”

   Model organismsContinuous dietary exposure0.5–2%Throughout development and adulthood

   Chronic Dietary Exposure to Methylparaben and Ethyl paraben Induces Developmental, Biochemical, and Behavioural Toxicity in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·15 Oct 2025Preprint

1. Methylparaben impairs locomotor performance in flies.

   “Both adult climbing and larval crawling performances were impaired, linking biochemical stress to neuromuscular dysfunction.”

   Model organismsContinuous dietary exposure0.5–2%Throughout development and adulthood

   Chronic Dietary Exposure to Methylparaben and Ethyl paraben Induces Developmental, Biochemical, and Behavioural Toxicity in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·15 Oct 2025Preprint

1. Methylparaben shortens lifespan in flies (Up to 50% decrease at 2% MP).

   “reduced median lifespan (up to 50% decrease at 2% MP)”

   Model organismsContinuous dietary exposure2%Throughout development and adulthood

   Chronic Dietary Exposure to Methylparaben and Ethyl paraben Induces Developmental, Biochemical, and Behavioural Toxicity in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·15 Oct 2025Preprint

1. Methylparaben is associated with nonmelanoma skin cancer in humans (aOR 1.69, 95% CI 1.20–2.37).

   “those in Q4 for MP exhibited 1.69-fold higher odds of nonmelanoma skin cancer than those in Q1 (aOR: 1.69; 95% CI: 1.20, 2.37)”

   HumansQ4 vs Q1 creatinine-adjusted urinary methylparaben

   Association between urinary paraben concentrations and skin cancer among US Adults

   Cancer epidemiology·17 Aug 2026

More on Nonmelanoma skin cancer

1. Methylparaben is associated with skin cancer in humans (aOR 1.46, 95% CI 1.13–1.87).

   “Individuals in the highest quartile (Q4) of urinary MP (≥ 242.01 μg/g) had significantly greater odds of total skin cancer (adjusted OR [aOR]: 1.46; 95% CI: 1.13, 1.87)”

   HumansQ4 vs Q1 creatinine-adjusted urinary methylparaben

   Association between urinary paraben concentrations and skin cancer among US Adults

   Cancer epidemiology·17 Aug 2026

More on Skin cancer