Muscle wasting
Disease1 paper1 finding
- Cells1
Interventions
1EDA2R knockdown
downin mice1
1 study
EDA2R knockdown
downin mice1
EDA2R knockdown decreases muscle wasting in mice.
Animalsin SBMA miceskeletal muscle
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways · bioRxiv · 30 Sep 2026 · Preprint
Latest
5Animals
Extracellular vesicle microRNA promotes muscle regeneration by suppressing AP2M1
Delivering miR-193b-3p improved muscle repair in injured mice and targeted a protein elevated in sarcopenic human tissue.
CellsPreprint
Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
AnimalsMitochondria
Inotodiol preserves muscle mass and function in aged mice
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.