ER unfolded protein response
downin mice1
Serotonin decreases ER unfolded protein response in mice.
“serotonin promotes serotonylation of HSP90β, which effectively reduces endoplasmic reticulum stress”
Animals
The EMBO journal16 Jun 2026
Cellular senescence
downin mice1
Serotonin decreases cellular senescence in mice.
“serotonin alleviates cellular senescence and aging phenotypes in the mouse”
Animals
The EMBO journal16 Jun 2026
Germline progenitor cells
upin worms1
Serotonin increases germline progenitor cells in worms.
“An adult-specific serotonin signal acts upstream of DAF-7 to increase the population of germline progenitors, but only in actively egg-laying worms.”
Model organismsin actively egg-laying wormsgermlinefemales
Developmental biology13 Mar 2026
flr-2
upin worms1
Serotonin increases flr-2 in worms.
“5-HT activates its receptor, MOD-1, in the post-synaptic interneurons that then secretes the neuropeptide FLR-2.”
Model organismsvia MOD-1 in post-synaptic interneurons
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2024Preprint
Distal colitis
upin mice1
Serotonin increases distal colitis in mice.
“distal colitis was more sensitive to 5-HT treatment”
Animalsdistal colitis in a mouse colitis model
Nature aging6 Feb 2024
Mitochondrial function
mixedin mice1
Serotonin is associated with mitochondrial function in mice.
“serotonin acts via its receptor 5HTR1B to modulate mitochondrial function”
Animalsvia its receptor 5HTR1B
The EMBO journal16 Jun 2026
Carcinoid tumor
Phase 3Terminated1 trial
Phase 3Terminated1 trial
Phase 1/2Results posted1 trial
Phase 1/2Results posted1 trial
Phase 1Completed1 trial
Company1 trialPhase 112 people
University of Western Ontario, Canada
1 trialPhase 38 people
1 trialPhase 1/293 people
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$2.1m
In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.
In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.