Depressive disorder

Disease3 papers

  • Human trial1
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Journal of Affective DisordersHumans

Persistent depression speeds frailty accumulation in older adults

Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of…Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of incident frailty.

Research SquareHumansPreprint

New postoperative depression links to higher dementia risk

Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia.Patients with new depression after major surgery showed an adjusted hazard ratio of 1.59 (95% CI 1.38–1.85) for incident dementia.

medRxivHumansPreprint

Accelerated epigenetic aging predicts major depression and brain changes after trauma

Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity…Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.