flr-2

1. Serotonin increases flr-2 in worms.

   “5-HT activates its receptor, MOD-1, in the post-synaptic interneurons that then secretes the neuropeptide FLR-2.”

   Model organismsvia MOD-1 in post-synaptic interneurons

   Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

   bioRxiv (Cold Spring Harbor Laboratory)·2 Mar 2024Preprint

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1. flr-2 activates p38 MAPK signalling in worms.

   “FLR-2 binding to its intestinal receptor, FSHR-1, induces the phase transition of the SARM domain protein TIR-1, thereby activating the p38-MAPK pathway.”

   Model organismsin B12-sensitive C. elegans mutant intestine

   Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

   Nature communications·2 Jun 2025

2. flr-2 activates p38 MAPK signalling in worms.

   “FLR-2 binds to FSHR-1, its cognate receptor in the intestine, and induces the phase transition of the SARM domain protein TIR-1, thereby activating the p38-MAPK pathway.”

   Model organismsintestine

   Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

   bioRxiv (Cold Spring Harbor Laboratory)·2 Mar 2024Preprint

More on p38 MAPK signalling