1 paper3 findings
Extracellular matrix remodeling-associated transcriptional module
upin mice1
Rlx@pnac4a activates extracellular matrix remodeling-associated transcriptional module in mice.
“RLX@PnAC4A activated a dominant, therapy-specific transcriptional module enriched in extracellular matrix remodeling and pro-regenerative signaling”
Animalsovariectomized mice
Bone-targeted drug delivery improves bone structure in mice
Materials today. Bio23 Sep 2026
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Trabecular microarchitecture and structural integrity
upin mice1
Rlx@pnac4a improves trabecular microarchitecture and structural integrity in mice.
“RLX@PnAC4A rapidly accumulated in bone tissue and significantly improved trabecular microarchitecture, bone formation dynamics, and structural integrity compared with free RLX.”
Animalsovariectomized mice; compared with free raloxifenebone
Bone-targeted drug delivery improves bone structure in mice
Materials today. Bio23 Sep 2026
Osteoclastogenesis
downin mouse cells1
Rlx@pnac4a decreases osteoclastogenesis in mouse cells.
“enhanced osteogenic differentiation, and suppressed osteoclastogenesis in a microenvironment-dependent manner.”
Cellsmicroenvironment-dependent
Bone-targeted drug delivery improves bone structure in mice
Materials today. Bio23 Sep 2026
In mice lacking ovaries, the targeted carrier delivered raloxifene to bone tissue and improved bone formation and structural integrity compared with the free drug.In mice lacking ovaries, the targeted carrier delivered raloxifene to bone tissue and improved bone formation and structural integrity compared with the free drug.