Quinolinic acid

1. Quinolinic acid protects against ischemic kidney injury in mice.

   “QA supplementation effectively alleviated the exacerbated kidney injury observed in male mice.”

   Animalsin male mice with ischemia-reperfusion injurykidneymales

   Sex Dimorphism of NAD +De Novo Biosynthesis Mediates Sex-Biased Susceptibility to Ischemia-Reperfusion-Induced Acute Kidney Injury

   Journal of the American Society of Nephrology : JASN·15 Jun 2026

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1. Quinolinic acid decreases lipid and ceramide metabolism in mice.

   “QA reduces hepatic lipid uptake by inhibiting the expression of lipoprotein lipase (LPL) and fatty acid translocase (CD36) in liver”

   Animalsin high-fat-diet fed miceliver

   Quinolinic acid protects mouse liver from high-fat diet induced MASLD by inhibiting lipid uptake gene expression

   European journal of pharmacology·13 Aug 2025

More on Lipid and ceramide metabolism

1. Quinolinic acid inhibits CD36 in mice.

   “QA reduces hepatic lipid uptake by inhibiting the expression of lipoprotein lipase (LPL) and fatty acid translocase (CD36) in liver”

   Animalsin high-fat-diet fed miceliver

   Quinolinic acid protects mouse liver from high-fat diet induced MASLD by inhibiting lipid uptake gene expression

   European journal of pharmacology·13 Aug 2025

More on CD36

1. Quinolinic acid inhibits LPL in mice.

   “QA reduces hepatic lipid uptake by inhibiting the expression of lipoprotein lipase (LPL) and fatty acid translocase (CD36) in liver”

   Animalsin high-fat-diet fed miceliver

   Quinolinic acid protects mouse liver from high-fat diet induced MASLD by inhibiting lipid uptake gene expression

   European journal of pharmacology·13 Aug 2025

More on LPL

1. Quinolinic acid decreases hepatic lipid accumulation in mice.

   “We observed a protective role for QA in preventing hepatic lipid accumulation in high-fat-diet fed mice”

   Animalsin high-fat-diet fed miceliver

   Quinolinic acid protects mouse liver from high-fat diet induced MASLD by inhibiting lipid uptake gene expression

   European journal of pharmacology·13 Aug 2025

More on Hepatic lipid accumulation

1. Quinolinic acid has no effect on NAD+ in worms.

   “these defects cannot be restored by any metabolites from the de novo synthesis pathway, including the direct QPRTase substrate quinolinic acid (QA)”

   Model organismsNAD+ salvage-precursor depleted medium

   De novo NAD⁺ synthesis is ineffective for NAD⁺ supply in axenically cultured Caenorhabditis elegans

   Communications biology·2 Apr 2025

More on NAD+