3-hydroxyanthranilic acid

1. 3-hydroxyanthranilic acid improves immune response in worms.

   “elevating physiological 3HAA can beneficially enhance both stress resilience and the immune response of C. elegans to bacterial pathogens during aging.”

   Model organismsduring aging, to bacterial pathogens

   Targeting kynurenine metabolism in aging and age-associated disease · GSA 2025 abstract · 31 Dec 2025

2. 3-hydroxyanthranilic acid improves immune response in worms.

   “elevating physiological 3HAA can beneficially enhance the immune response of C. elegans to bacterial pathogens during aging.”

   Model organismsduring aging

   A NEW ROLE FOR KYNURENINE METABOLISM IN THE AGE-ASSOCIATED DECLINE OF THE BACTERIAL IMMUNE RESPONSE · GSA 2024 abstract · 31 Dec 2024

Immune response →

1. 3-hydroxyanthranilic acid extends lifespan in mice.

   “elevating physiological levels of the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3HAA) via either direct supplementation or inhibition of the enzyme that degrades 3HAA, 3HAA dioxygenase (HAAO), extends lifespan and delays age-associated health decline in both roundworms and mice.”

   Animals

   Targeting kynurenine metabolism in aging and age-associated disease · GSA 2025 abstract · 31 Dec 2025

2. 3-hydroxyanthranilic acid extends lifespan in worms.

   “elevating physiological levels of the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3HAA) via either direct supplementation or inhibition of the enzyme that degrades 3HAA, 3HAA dioxygenase (HAAO), extends lifespan”

   Model organisms

   Targeting kynurenine metabolism in aging and age-associated disease · GSA 2025 abstract · 31 Dec 2025