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Ppar-gamma agonists

Intervention

3 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: CIHR Skin Research Training Centre and others
  • Animals2

Outcomes

2

Polyposis

downin mice1

1 study

  1. Ppar-gamma agonists decrease polyposis in mice.

    “PPAR-γ agonists or supplementation with dietary soluble fibre in the form of inulin reverted inflammatory and polyposis phenotypes.”

    Animalsin Il10-/- mice colonized with pks+ E. coli on LC diet

    Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer

    Nature microbiologyMar 3, 2025

Metabolic benefits

upin animals1

1 study

  1. Ppar-gamma agonists improve metabolic benefits.

    “Synchronizing PPARγ activity with nutrient conditions through feeding-timed agonism optimizes their metabolic benefits and safety.”

    Animalsfeeding-timed agonism

    Deciphering the decline of metabolic elasticity in aging and obesity

    Cell metabolismAug 24, 2023

Funding

1 grant since 2017

Veterans Affairs

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