InterventionPartial reprogramming
14 papers study it14 findings
Aging-related metabolites
downin mouse cells2
Chemical reprogramming decreases aging-related metabolites in mouse cells.
“we observed a reduction in the accumulation of aging-related metabolites”
Cellsfibroblasts
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
eLifePreprint
Chemical reprogramming decreases aging-related metabolites in mouse cells.
“we observed a reduction in the accumulation of aging-related metabolites”
Cellsin fibroblasts from young and aged micefibroblast
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
bioRxiv : the preprint server for biologyPreprint
Oxidative phosphorylation
upin mouse cells2
Chemical reprogramming activates oxidative phosphorylation in mouse cells.
“with the most notable signature being an upregulation of mitochondrial oxidative phosphorylation”
Cellsfibroblasts
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
eLifePreprint
Chemical reprogramming increases oxidative phosphorylation in mouse cells.
“with the most notable signature being an upregulation of mitochondrial oxidative phosphorylation”
Cellsin fibroblasts from young and aged micefibroblast
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
bioRxiv : the preprint server for biologyPreprint
Alveolar progenitor-like state
upin human cells1
Chemical reprogramming induces alveolar progenitor-like state in human cells.
“enables efficient conversion of adult human AT2 cells into a highly expandable alveolar progenitor-like state”
Cellsalveolar type 2 cell
Adult human lung cells became expandable precursor-like cells
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Uniform CD13-low cell populations
upin human cells1
Chemical reprogramming induces uniform CD13-low cell populations in human cells.
“Chemical reprogramming produced uniform CD13-low populations without pluripotency marker induction.”
Cellshuman-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Age-associated gene expression
downin human cells1
Chemical reprogramming decreases age-associated gene expression in human cells.
“Both reprogramming methods reduced senescence, mitochondrial ROS, and age-associated gene expression, with chemical reprogramming matching or exceeding OSKM efficacy.”
Cellsprogerin-induced aged fibroblasts and primary fibroblasts from donors over 85human-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Mitochondrial ROS
downin human cells1
Chemical reprogramming decreases mitochondrial ROS in human cells.
“Both reprogramming methods reduced senescence, mitochondrial ROS, and age-associated gene expression, with chemical reprogramming matching or exceeding OSKM efficacy.”
Cellsprogerin-induced aged fibroblasts and primary fibroblasts from donors over 85human-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Cellular senescence
downin human cells1
Chemical reprogramming decreases cellular senescence in human cells.
“chemical reprogramming lowered senescence during active treatment.”
Cellshuman-optimized protocolfibroblastduring active treatment
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Epigenetic regulation of gene expression
upin human cells1
Chemical reprogramming improves epigenetic regulation of gene expression in human cells.
“chemical-induced partial reprogramming can improve key drivers of aging including genomic instability and epigenetic alterations in aged human cells.”
Cellssomatic cells
Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan
EMBO molecular medicine
DNA damage response
downin human cells1
Chemical reprogramming decreases DNA damage response in human cells.
“chemical-induced partial reprogramming can improve key drivers of aging including genomic instability and epigenetic alterations in aged human cells.”
Cellssomatic cells
Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan
EMBO molecular medicine
Biological age
downin mouse cells1
Chemical reprogramming decreases biological age in mouse cells.
“partial chemical reprogramming reduces the biological age of mouse fibroblasts”
Cellsfibroblasts
Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation
eLifePreprint
National Institute of Neurological Disorders and StrokeUS$1.4mJapan Society for the Promotion of ScienceJP¥26mEuropean Innovation Council€3m
Creation of data-driven chemical reprogramming technologies by experiment optimization AI
Japan Society for the Promotion of ScienceNagoya UniversityJP¥26m2024–2027
Functional chemical reprogramming of cancer cells to induce antitumor immunity
European Innovation CouncilLunds Universitet€3m2024–2026
Chemical Reprogramming of Traumatic Brain Injury
National Institute of Neurological Disorders and StrokeUT Southwestern Medical CenterUS$354.4k2017–2022
Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.