Transcriptomic clock

Biomarker5 papers2 findings

Humans1
Model organisms1
Cells1
In silico2

Interventions

1

mTOR inhibitors

downin human cells1Very low certainty

1 study

mTOR inhibitors decrease transcriptomic clock in human cells.
“Furthermore, drug treatment reduced both epigenetic and transcriptomic age”
Cellsin progeria patient iPSC-VSMCsvascular smooth muscle cell
Targeting Vascular Aging in Progeria by mTOR Inhibitors from Multi-Omics Screening · GSA 2025 abstract · 31 Dec 2025

mTOR inhibitors →

Associations

1

Epigenetic clock

upin silico1

1 study

Epigenetic clock is associated with transcriptomic clock in silico.
In silicosorted immune cell-types
The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality · Nature communications · 28 Jul 2026

Epigenetic clock →

Latest

6

BiogerontologyIn silico22 Sep

Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories

Nature CommunicationsHumans21 Sep

Sex-specific trajectories of nonlinear immune aging at single-cell level

Immune response

iScienceModel organisms30 Aug

Form and function of actin impacts actin health and aging

Nature CommunicationsIn silico27 Aug

The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality

Blood and immune system

Aging CellAnimals22 Aug

LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation

GSA 2025 AbstractCells3 Jan

Targeting Vascular Aging in Progeria by mTOR Inhibitors from Multi-Omics Screening

mTOR inhibitors