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Lopinavir

Intervention

2 papers2 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 3 more
  • Humans1
  • Animals1

Outcomes

1

Cellular senescence

upin mice1

1 study

  1. Lopinavir induces cellular senescence in mice.

    “lopinavir accelerated cellular senescence by inhibiting Zmpste24 and interfering nuclear membrane stability”

    Animals

    AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

    Bone research3 Jun 2025

More on Cellular senescence

Associations

1

Osteoarthritis

upin mice1

1 study

  1. Lopinavir raises the risk of osteoarthritis in mice.

    “among all antiviral drugs, lopinavir had the most detrimental impact on cartilage anabolism, accelerating cartilage senescence and promoting mouse OA development.”

    Animals

    AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition

    Bone research3 Jun 2025

More on Osteoarthritis

Latest

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