DDIT3

1. DDIT3 is required for mitochondrial unfolded protein response in mouse cells.

   “Adenoviral-mediated shRNA CHOP knockdown and pharmacological JNK inhibition confirmed this axis as an mtROS-sensitive driver of the mtUPR.”

   Cellsproteotoxic stress with adenoviral shRNA knockdownC2C12 myotubes

   A redox-sensitive JNK-CHOP signaling axis drives running stress-induced mtUPR activation in aged skeletal muscle · GSA 2025 abstract · 31 Dec 2025

Mitochondrial unfolded protein response →

1. ER unfolded protein response increases DDIT3 in mice.

   Animalsagingheartfemalesn = 10

   Mitochondrial Dysfunction in Aging: The Female Heart at Risk · AHA Scientific Sessions 2025 abstract · 3 Nov 2025

ER unfolded protein response →