Hydrogen

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: National Natural Science Foundation of China and 7 more

Animals2

Outcomes

Goblet cell abundance

upin mice1

1 study

Hydrogen increases goblet cell abundance in mice.
“increases goblet cell abundance, and modulates gut microbiota, promoting intestinal repair”
Animalsradiation enteritisintestine
Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice
Nature communications17 Oct 2025

Inflammation

downin mice1

1 study

Hydrogen inhibits inflammation in mice.
“Beyond RONS scavenging, the released hydrogen induces anti-inflammatory macrophage polarization”
Animalsradiation enteritisintestine
Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice
Nature communications17 Oct 2025

Latest

55 in 12 months

bioRxiv9 Oct

Metabolic pause protects donor livers and aids survival in rats

A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.A flush combining a metabolic inhibitor with a mitochondrial protectant reduced tissue injury and improved survival after warm storage in rat liver transplants.

Preprint: experiments in ratsInterventions

Paper

bioRxiv1 Oct

Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice

Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.Targeting hydrogen sulfide generation to endothelial mitochondria mitigated senescence programs and reversed vascular remodeling in aged mice.

Preprint: experiments in miceInterventions

Paper

Current Issues in Molecular Biology26 Sep

Peroxisomal enzyme ACOX-1.2 enables extended lifespan in long-lived roundworms

Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans.Inhibiting the fatty acid oxidation enzyme suppresses both autophagy and longevity in long-lived rsks-1 mutant Caenorhabditis elegans.

Experiments in wormsMechanisms

Paper

Antioxidants26 Sep

Senescent human astrocytes impair neuronal mitochondrial function through released factors

Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.Conditioned medium from damaged astrocytes alters extracellular mitochondria and triggers ATP depletion and oxidative stress in human postmitotic neurons.

Experiments in human cellsCellular senescence

Paper

bioRxiv17 Sep