Chemogenetic hydrogen sulfide production reverses vascular remodeling in aged mice

In aged mice, researchers tested a targeted chemogenetic system to rescue vascular senescence, according to a new preprint. The study notes that hydrogen sulfide bioavailability declines during aging and atherosclerosis, which is associated with endothelial senescence. To address this decline, the authors engineered a remote-control, endothelial-specific, mitochondria-targeted chemogenetic tool. This platform enabled precise spatiotemporal control over hydrogen sulfide generation. Using this targeted approach, the team mitigated endothelial senescence-driven programs. The controlled release of hydrogen sulfide also successfully reversed vascular remodeling in the animals, presenting a targeted strategy to address vascular decline.