Hormonal therapy
Hormonal therapy has been studied in 8 papers since 2018: 3 observational studies in people, 5 reviews; 5 in the past year. The newest paper, Jun 12, 2026: “Retrospective case-control study of pre-diagnosis observational and prescription data in Parkinson's disease”.
8 papers study it7 findingsUpdated
See all 8 papers on hormonal therapy
At a glance
Independent labs found the same change in people. 4 independent labs in 3 countries.
“Hormonal therapies and triptan medications were associated with lower disease incidence but were more frequently prescribed to individuals with more favourable biometric risk profiles, suggesting potential confounding.”
None of its findings points the other way.
- 4 independent labs in 3 countries
- Funders: Health Data Research UK and 2 more
- Humans3
What did studies of hormonal therapy find?
2Studies of hormonal therapy measured 2 outcomes; the most studied are mortality (1 study) and side effects (1).
Mortality
downin humans1HR 0.68
1 study
Mortality
downin humans1HR 0.68
Hormonal therapy is linked with lower mortality in humans (HR 0.68 (95% CI 0.57-0.80)).
“all-cause mortality (HR 0.68; 0.57-0.80)”
Humans1-yearfemales
Proceedings (Baylor University. Medical Center)
Side effects
downin humans1
1 study
Side effects
downin humans1
Hormonal therapy decreases side effects in humans (compared with systemic hormonal treatment).
“Topical hormonal treatments often have fewer side effects than systemic alternatives.”
Reviewcompared with systemic hormonal treatmenttopicalfemales
Life (Basel, Switzerland)
What is hormonal therapy linked with?
4Studies link hormonal therapy with 4 measures, most often Parkinson's disease (1 study), atrial fibrillation (1) and hospitalization (1).
Parkinson's disease
downin humans1
1 study
Parkinson's disease
downin humans1
Hormonal therapy is linked with a lower risk of Parkinson's disease in humans (possible confounding by biometric risk profile).
“Hormonal therapies and triptan medications were associated with lower disease incidence but were more frequently prescribed to individuals with more favourable biometric risk profiles, suggesting potential confounding.”
Humanspossible confounding by biometric risk profile
Scientific reports
Atrial fibrillation
downin humans1HR 0.76
1 study
Atrial fibrillation
downin humans1HR 0.76
Hormonal therapy is linked with a lower risk of atrial fibrillation in humans (HR 0.76 (95% CI 0.62-0.94)).
“atrial fibrillation (HR 0.76; 0.62-0.94)”
Humans1-yearfemales
Proceedings (Baylor University. Medical Center)
Hospitalization
downin humans1HR 0.55
1 study
Hospitalization
downin humans1HR 0.55
Hormonal therapy is linked with a lower risk of hospitalization in humans (HR 0.55 (95% CI 0.54-0.57)).
“hospitalization (HR 0.55; 0.54-0.57)”
Humans1-yearfemales
Proceedings (Baylor University. Medical Center)
Major adverse cardiovascular events
downin humans1HR 0.72
1 study
Major adverse cardiovascular events
downin humans1HR 0.72
Hormonal therapy is linked with a lower risk of major adverse cardiovascular events in humans (HR 0.72 (95% CI 0.62-0.83)).
“hormonal therapy was associated with a lower risk of MACE (hazard ratio [HR] 0.72; 95% confidence interval 0.62-0.83)”
Humans1-yearfemales
Proceedings (Baylor University. Medical Center)
Funding
2 grants since 2018National Cancer Institute$1.4MEconomic and Social Research Council
Economic and Social Research CouncilUniversity of Strathclyde2021–2025
National Cancer InstituteUniversity of California, San Francisco$363K2017–2022
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