Serum urea

1. Hs-n decreases serum urea in mice.

   “significantly lowered serum urea, accompanied by reduced renal NOX4 expression”

   Animals

   ROS-Responsive H₂S Release Attenuates Renal Aging by Preserving Mitochondrial Function and Mitigating Oxidative Stress

   ACS applied materials & interfaces·Jun 12, 2026

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1. Milk protein increases serum urea in humans (PInteraction < 0.001).

   “Serum urea increased in the protein group, whereas no changes were observed in the placebo group (PInteraction < 0.001).”

   Human trial31 g/day12 weeksn = 116

   Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial

   Journal of cachexia, sarcopenia and muscle·Mar 7, 2019

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1. Cerivastatin decreases serum urea in mice (COL4A3 knockout mice) (164 vs 235 mmol/l).

   “Early cerivastatin treatment reduced cholesterol levels (113+/-13 vs 141+/-19 mmol/l in untreated animals, P<0.05) and serum urea (164 vs 235 mmol/l, day 66, P<0.05).”

   AnimalsCOL4A3 knockout mice

   Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

   Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·Feb 6, 2007

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