Propranolol

1. Propranolol has no effect on lifespan in dogs.

   “Although propranolol did not appear to influence treatment outcomes, our results revealed long-term survival in young adult dogs”

   Animalscanine hemangiosarcoma receiving doxorubicinn = 20

   Younger Age Is Associated with Favorable Outcomes in Adult Dogs with Hemangiosarcoma Receiving Adjuvant Doxorubicin Chemotherapy: Results from the PRO-DOX Study

   Research square·5 May 2025Preprint

2. Propranolol extends lifespan in worms.

   “five compounds (all-trans retinoic acid, berberine, fisetin, propranolol, and ritonavir) extended lifespan in Caenorhabditis elegans.”

   Model organisms

   Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

   eLife·27 Dec 2024Preprint

3. Propranolol extends lifespan in rats.

   “calcium antagonist and the beta-receptor blocker prolonged the life span more than the diuretic and vasodilator”

   Animalsoral long-term treatmentoral

   Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs

   Journal of cardiovascular pharmacology·1 Jan 1989

1. Propranolol increases MAPT accumulation in mice.

   “Inhibition of β2-AR by propranolol (30 mg/kg, intragastric administration 1 h before each AE session) restrained AE-attenuated MAPT accumulation by inhibiting autophagy-lysosomal flux in MAPT P301L mice.”

   AnimalsAE-treated MAPT P301L mice30 mg/kg

   Aerobic Exercise Attenuates Autophagy-Lysosomal Flux Deficits via β2-AR-Mediated ESCRT-III Subunit CHMP4B in Mice With Human MAPT P301L

   Aging cell·26 Jul 2025

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1. Propranolol decreases lesion burden.

   “The β-blocker propranolol and the superoxide dismutase mimetic REC-994 have also shown effectiveness in attenuating lesion burden in preclinical studies.”

   Reviewin preclinical studies

   Current and Future Treatment Options for Cerebral Cavernous Malformations

   Stroke (Hoboken, N.J.)·22 Mar 2024

1. Propranolol inhibits caloric restriction in mice.

   “The effect of CR on bone mass was inhibited by administration of a beta-adrenergic blocker, propranolol.”

   Animalsco-treatment with propranololmales

   Life-long caloric restriction reveals biphasic and dimorphic effects on bone metabolism in rodents

   Endocrinology·8 Nov 2007

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1. Propranolol inhibits glucose output in rat cells.

   “The isoproterenol-stimulated glucose output in hepatocytes from senescent rats was inhibited concentration dependently by propranolol, ICI 118,551, ICi 89,406, and CGP 20,712A.”

   Cellsconcentration dependentlyhepatocytes

   Influence of age on the beta 1- and beta 2-adrenergic receptors in rat liver

   Molecular pharmacology·1 Oct 1992

More on Glucose output

1. Propranolol decreases blood pressure in rats.

   “oral long-term treatment with verapamil, propranolol, hydrochlorothiazide, and dihydralazine attenuated the development of hypertension”

   Animalsoral long-term treatmentoral

   Development of hypertension and life span in stroke-prone spontaneously hypertensive rats during oral long-term treatment with various antihypertensive drugs

   Journal of cardiovascular pharmacology·1 Jan 1989

More on Blood pressure

1. Propranolol inhibits protein secretion in rat cells.

   “the beta-adrenergic antagonist (+/-)-propanolol inhibited (-)-isoproterenol-stimulated protein secretion from parotid cell aggregates of young and old animals equally.”

   Cellsparotid gland

   Beta-adrenergic regulation of rat parotid gland exocrine protein secretion during aging

   Mechanisms of ageing and development·1 Feb 1981

More on Protein secretion